A growing number of best cbd for rheumatoid arthritis suffering from rheumatoid arthritis are turning to CBD, a natural compound that’s been shown in preclinical studies to relieve the pain and inflammation associated with this common condition. But there are a lot of CBD products out there, and it can be difficult to know which one is right for you. That’s why we created this guide to help you choose the best cbd for rheumatoid arthritis.

In a 2019 poll conducted by the Arthritis Foundation, 29 percent of respondents reported currently using CBD to manage their RA symptoms. And anecdotal evidence suggests that CBD can help a variety of arthritis symptoms, including reduced inflammation and improved sleep and mood.

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Researchers have also found that CBD can target synovial fibroblasts, which play a crucial role in regulating the inflammation and pain behavior of joints. This is because CBD inhibits a protein called TRPV1 and increases the expression of PLC2 in fibroblasts, resulting in a decrease in pro-inflammatory cytokines such as IL-6 and MMP-3. Additionally, CBD increases intracellular calcium levels and inhibits PoPo3 uptake in fibroblasts, all of which helps reduce inflammatory signaling and inhibits nociception.

In a study assessing the effectiveness of CBD for reducing the severity of arthritic pain, participants were asked to rate their pain on a 0-to-10 numeric pain scale before and after consuming CBD. They were also asked to rank their improvement in physical function and quality of life on a similar 5-point Likert scale, known as the Patient Global Impression of Change (PGIC). Overall, participants experienced a 44% reduction in numerical pain score and a 2.58-point reduction in pain intensity. Pairwise comparisons by diagnosis type showed that the osteoarthritis group exhibited a higher percentage and point reduction in pain than RA and other autoimmune arthritis groups.